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ProductsBack/Betulinic acid (>99%) [472-15-1]
Chemical Structure
Chemical Structure
Chemical Structure

Betulinic acid (>99%) [472-15-1]

Research Use Only
AG-CN2-0415
AdipoGen Life Sciences
CAS Number472-15-1
DownloadMSDS
Product group Chemicals
Estimated Purity>99%
Molecular Weight456.7
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Betulinic acid (>99%) [472-15-1]
  • Delivery Days Customer
    10
  • CAS Number
    472-15-1
  • Certification
    Research Use Only
  • Estimated Purity
    >99%
  • Molecular Formula
    C30H48O3
  • Molecular Weight
    456.7
  • Scientific Description
    Anti-HIV compound [1]. Anticancer compound [2]. Apoptosis inducer [2]. Modulator of NF-kappaB [3,4,8]. Potent DNA topoisomerase II inhibitor [5]. Potent proteasome activator [6]. Antimalarial compound [7]. - Chemical. CAS: 472-15-1. Formula: C30H48O3. MW: 456.7. Isolated from Platanus acerifolia bark. Anti-HIV compound. Anticancer compound. Apoptosis inducer. Modulator of NF-kappaB. Potent DNA topoisomerase II inhibitor. Potent proteasome activator. Antimalarial compound.
  • SMILES
    [H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200

References

  • Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids: T. Fujioka, et al.; J. Nat. Prod. 57, 243 (1994)
  • Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis: E. Pisha, et al.; Nat. Med. 1, 1046 (1995)
  • Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9: Y. Takada & B.B. Aggarwal: J. Immunol. 171, 3278 (2003)
  • Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy: H. Kasperczyk, et al.; Oncogene 24, 6945 (2005)
  • Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica: S. Wada & R. Tanaka; Chem. Biodivers. 2, 689 (2005)
  • Activation and inhibition of the proteasome by betulinic acid and its derivatives: L. Huang, et al.; FEBS Lett. 581, 4955 (2007)
  • Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice: M.S. de Sa, et al.; Parasitol. Res. 105, 275 (2009)
  • Betulinic acid, a natural compound with potent anticancer effects: F.B. Mullauer, et al.; Anticancer Drugs 21, 215 (2010)