BI-0252

MedChem Express

BI-0252 [1818291-27-8]

10

1818291-27-8

C30H26Cl2FN3O3

566.45

BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC 50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis [1] .

ClC1=C(F)C([C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)N(CC5CC5)[C@@H]6[C@H]2N[C@@H](C7=CC=C(C(O)=O)C=C7)C6)=CC=C1

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