Bio-Connect

BI-0474

HY-148278
MedChem Express
Estimated Purity99.83
Product group Chemicals
Molecular Weight587.74
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Overview

  • Supplier
    MedChem Express
  • Product Name
    BI-0474
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Estimated Purity
    99.83
  • Molecular Formula
    C30H37N9O2S
  • Molecular Weight
    587.74
  • Scientific Description
    BI-0474 is a potent KRAS G12C inhibitor with an IC 50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models [1] .
  • SMILES
    N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(N5[C@@H](C)CN(C)CC5)=CC(N6CCN(C(C=C)=O)CC6)=C4)=NO3)CCC2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200