Bid antibody

GeneTex

Bid antibody

9

Western Blot

Research Use Only

Polyclonal

Unconjugated

Bid

BH3 interacting domain death agonist

2700049M22Rik; AI875481; AU022477; BH3-interacting domain death agonist; p22 BID

Rabbit

IgG

BH3-interacting domain death agonist

BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl 2 family. BID interacts with both Bcl 2 and Bax through its BH3 domain. It usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.

Mouse

-20°C or -80°C,2°C to 8°C

12352203