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Bim-BLK-A

Bim-BLK-A

T26817
TargetMol Chemicals
Molecular Weight469.44
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Product group Chemicals
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Bim-BLK-A
  • Delivery Days Customer
    999
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Bim-BLK-A
  • Molecular Formula
    C20H18F3N3O5S
  • Molecular Weight
    469.44
  • Scientific Description
    Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer chain (ETC). Bim-BLK-A protects the integrity of the ETC and allows treated cells to continue to proliferate after apoptosis induction.
  • Shelf life instruction
    3 years
  • SMILES
    O=C1C=CC(C2=NC(S(=O)(C)=O)=NC(C(F)(F)F)=C2)=CN1CC3=CC=C(OC)C(OC)=C3
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway. Jiang X et al., 2016 Jul 21, Mol Cell
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