Biotin Anti-Mouse CD279/PD-1 Antibody

Reddot Biotech

Biotin Anti-Mouse CD279/PD-1 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

29F.1A12

0.5 mg/ml

Biotin

Pdcd1

programmed cell death 1

Ly101; mPD-1; PD-; PD-1; Pdc; Pdc1; programmed cell death 1 protein; programmed cell death protein 1; protein PD-1

Rat

IgG2a

CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Mouse

2°C to 8°C

12352203