Biotinylated Human LILRA4/CD85g Protein (LIL-HM4A4B)

KACTUS

Biotinylated Human LILRA4/CD85g Protein (LIL-HM4A4B)

9

Research Use Only

Biotin

>95%

Leukocyte immunoglobulin-like receptor subfamily A member 4

LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.

-20°C or -80°C,-80°C

12352202