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ProductsBack/Bisindolylmaleimide IX . methansulfonate [Ro 31-8220]
Chemical Structure
Chemical Structure
Chemical Structure

Bisindolylmaleimide IX . methansulfonate [Ro 31-8220]

Research Use Only
AG-CR1-0111
AdipoGen Life Sciences
CAS Number138489-18-6
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight457.6 . 96.1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Bisindolylmaleimide IX . methanesulfonate [138489-18-6]
  • Delivery Days Customer
    10
  • CAS Number
    138489-18-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C25H23N5O2S . CH4O3S
  • Molecular Weight
    457.6 . 96.1
  • Scientific Description
    Chemical. CAS: 138489-18-6. Formula: C25H23N5O2S . CH4O3S. MW: 457.6 . 96.1. Selective and cell permeable protein kinase C (PKC) inhibitor. Inhibits the stimulation of insulin secretion by glucose. Inhibits T cell activation. Apoptosis inducer. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Transcription inhibitor. Induces TNF receptor family-mediated cell death. Pim-1 kinase inhibitor. Antitumor compound. - Selective and cell permeable protein kinase C (PKC) inhibitor [1, 2, 3]. Inhibits the stimulation of insulin secretion by glucose [4, 11]. Inhibits T cell activation [5]. Apoptosis inducer [6, 8, 9,10, 13]. Potent glycogen synthase kinase-3 (GSK-3) inhibitor [7]. Transcription inhibitor [9]. Induces TNF receptor family-mediated cell death [10]. Pim-1 kinase inhibitor [12]. Antitumor compound [13].
  • SMILES
    CS(O)(=O)=O.CN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CN(CCCSC(N)=N)C2=C1C=CC=C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Potent selective inhibitors of protein kinase C: P.D. Davis, et al.; FEBS Lett. 259, 61 (1989)
  • RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages: P. Dieter & E. Fitzke; BBRC 181, 396 (1991)
  • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
  • Inhibition of glucose-stimulated insulin secretion by Ro 31-8220, a protein kinase C inhibitor: S.J. Persaud & P.M. Jones; Endocrine 3, 285 (1995)
  • RO 31-8220, a novel protein kinase C inhibitor, inhibits early and late T cell activation events: L. Geiselhart, et al.; Transplantation 61, 1637 (1996)
  • Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3: L. Shen & R.I. Glazer; Biochem. Pharmacol. 55, 1711 (1998)
  • The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity: I. Hers, et al.; FEBS Lett. 460, 433 (1999)
  • The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C: Z. Han, et al.; Cell Death Differ. 7, 521 (2000)
  • Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription: O.W. Rokhlin, et al.; J. Biol. Chem. 277, 33213 (2002)
  • Bisindolylmaleimide IX Induces Reversible and Time-Dependent Tumor Necrosis Factor Receptor Family-Mediated Caspase Activation and Cell Death: O.W. Rokhlin & M.B. Cohen; Cancer Biol. Ther. 2, 266 (2003)