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ProductsBack/Bisindolylmaleimide V [Ro 31-6045]
Chemical Structure
Chemical Structure
Chemical Structure

Bisindolylmaleimide V [Ro 31-6045]

Research Use Only
AG-CR1-0023
AdipoGen Life Sciences
CAS Number113963-68-1
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight341.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Bisindolylmaleimide V [113963-68-1]
  • Delivery Days Customer
    10
  • CAS Number
    113963-68-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C21H15N3O2
  • Molecular Weight
    341.4
  • Scientific Description
    Chemical. CAS: 113963-68-1. Formula: C21H15N3O2. MW: 341.4. Negative control for protein kinase C (PKC) inhibitors. S6K inhibitor. Necrosis inhibitor. - Negative control for protein kinase C (PKC) inhibitors [1, 2]. S6K inhibitor [3]. Necrosis inhibitor [4].
  • SMILES
    CN1C(=O)C(C2=CNC3=CC=CC=C23)=C(C1=O)C1=CNC2=C1C=CC=C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides: P.D. Davis, et al.; J. Med. Chem. 35, 177 (1992)
  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C: D. Toullec, et al.; J. Biol. Chem. 266, 15771 (1991)
  • Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling: N. Marmy-Conus, et al.; FEBS Lett. 519, 135 (2002)
  • Bisindolylmaleimide I and V inhibit necrosis induced by oxidative stress in a variety of cells including neurons: R. Asakai, et al.; Neurosci. Res. 44, 297 (2002)