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ProductsBack/Bisindolylmaleimide X . hydrochloride [Ro 31-8425]
Chemical Structure
Chemical Structure
Chemical Structure

Bisindolylmaleimide X . hydrochloride [Ro 31-8425]

Research Use Only
AG-CR1-0113
AdipoGen Life Sciences
CAS Number131848-97-0
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight424.5 . 36.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Bisindolylmaleimide X . hydrochloride [131848-97-0, 145317-11-9]
  • Delivery Days Customer
    10
  • CAS Number
    131848-97-0
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C26H24N4O2 . HCl
  • Molecular Weight
    424.5 . 36.5
  • Scientific Description
    Chemical. CAS: 145317-11-9131848-97-0 (free base). Formula: C26H24N4O2 . HCl. MW: 424.5 . 36.5. Selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Inhibits superoxide generation in human neutrophils. - Selective protein kinase C (PKC) inhibitor [1-3]. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2) [3]. Inhibits superoxide generation in human neutrophils [1].
  • SMILES
    CC(C)(C=C)C12CC3N(C1NC1=C2C=CC=C1)C(=O)C1CC2(C(NC4=C2C=CC=C4)N1C3=O)C(C)(C)C=C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli: R.E. Muid, et al.; FEBS Lett. 293, 169 (1991)
  • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
  • Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)