Bisindolylmaleimide XI . hydrochloride [Ro 32-0432]

Name: Bisindolylmaleimide XI . hydrochloride [Ro 32-0432]
SKU: AG-CR1-0109_A27
Price: 94 EUR
Availability: BackOrder

AG-CR1-0109

CAS Number145333-02-4

Product group Chemicals

Estimated Purity>98%

Molecular Weight452.5 . 36.5

Overview

Supplier
AdipoGen Life Sciences
Product Name
Bisindolylmaleimide XI . hydrochloride [145333-02-4]
Delivery Days Customer
10
CAS Number
145333-02-4
Certification
Research Use Only
Estimated Purity
>98%
Molecular Formula
C28H28N4O2 . HCl
Molecular Weight
452.5 . 36.5
Scientific Description
Chemical. CAS: 145333-02-4. Formula: C28H28N4O2 . HCl. MW: 452.5 . 36.5. Selective cell permeable protein kinase C (PKC) inhibitor. G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor. Prevents T cell-driven chronic inflammatory responses in vivo. - Selective cell permeable protein kinase C (PKC) inhibitor. G protein-coupled receptor kinase (GRK-5) inhibitor. Less potent GRK-2 or GRK-3 inhibitor. Prevents T cell-driven chronic inflammatory responses in vivo.
SMILES
Cl.CN(C)CC1CCN2C(C1)=C(C1=C2C=CC=C1)C1=C(C(=O)NC1=O)C1=CN(C)C2=C1C=CC=C2
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
51202000

Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation: A.M. Birchall, et al.; J. Pharmacol. Exp. Ther. 268, 922 (1994)
Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development: P.G. Goekjian & M.R. Jirousek; Curr. Med. Chem. 6, 877 (1999) (Review)
Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors: N. Aiyar, et al.; Eur. J. Pharmacol. 403, 1 (2000)