BMS-1166-N-piperidine-CO-N-piperazine [2447066-14-8]
HY-131386
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product NameBMS-1166-N-piperidine-CO-N-piperazine [2447066-14-8]
- Delivery Days Customer10
- CAS Number2447066-14-8
- CertificationResearch Use Only
- Molecular FormulaC41H43ClN4O5
- Molecular Weight707.26
- Scientific DescriptionBMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
- SMILESO=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)N7CCNCC7
- UNSPSC41115800