BMS-1166-N-piperidine-CO-N-piperazine (dihydrochloride) [2691796-83-3]
HY-131386A
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product NameBMS-1166-N-piperidine-CO-N-piperazine (dihydrochloride) [2691796-83-3]
- Delivery Days Customer10
- CAS Number2691796-83-3
- CertificationResearch Use Only
- Estimated Purity95.01
- Molecular FormulaC41H45Cl3N4O5
- Molecular Weight780.18
- Scientific DescriptionBMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
- SMILESN#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(C=C2CN6CCCCC6C(N7CCNCC7)=O)Cl)=C1.Cl.Cl
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41115800