BMS-195614

MedChem Express

BMS-195614 [182135-66-6]

5

182135-66-6

99.5%

C29H24N2O3

448.51

BMS-195614 (BMS 614) is an orally active neutral RARalpha -selective antagonist with a K i of 2.5 nM. BMS-195614 restores the expression of Bcl2 . BMS-195614 inhibits the transactivation of NF-kappaB , AP-1 and PPAR . BMS-195614 downregulates the expression of IL-6 and VEGF . BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis [1] [2] [3] [4] [5] .

O=C(O)C1=CC=C(NC(C2=CC=C3C(C)(C)CC=C(C4=CC5=CC=CC=C5N=C4)C3=C2)=O)C=C1

-20°C

12352200