BMS-599626 (dihydrochloride)

MedChem Express

BMS-599626 (dihydrochloride)

5

Research Use Only

C27H29Cl2FN8O3

603.48

BMS-599626 dihydrochloride is a small molecule pan-HER (human epidermal growth factor receptor) kinase inhibitor. BMS-599626 dihydrochloride primarily targets HER1 ( IC 50 =20 nmol/L) and HER2 ( IC 50 =30 nmol/L) kinase activity in the HER family. BMS-599626 inhibits the kinase activity of HER1 and HER2 by competing with their ATP-binding sites, and can inhibit the downstream signaling pathway by blocking the heterodimer formation of HER1 and HER2 . BMS-599626 dihydrochloride can be used to study the antitumor effects of multiple HER1 or HER2 overexpressed tumor models [1] .

FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C(NC(OC[C@@H]6COCCN6)=O)=C5)C)=C3)=CC=C1.Cl.Cl

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