BMS-665053 [1173435-64-7]

TargetMol Chemicals

BMS-665053 [1173435-64-7]

72

Chemical

Research Use Only

BMS-665053

C16H14Cl3F2N3O2

424.66

BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM) that inhibits CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM). It is also efficacious in the Defensive Withdrawal model of anxiety in rats and has low in vivo clearance [Cl = 17 mL/min/kg, t1/2 = 7.8 h].

3 years

[C@@H](C)(N1C(=O)C(NC2=C(Cl)C=C(OC(F)F)C=C2Cl)=NC(Cl)=C1)C3CC3

-20°C

12352200