BMS-833923 (XL-139) [1059734-66-5]

Biorbyt

BMS-833923 (XL-139) [1059734-66-5]

16

1059734-66-5

Research Use Only

C30H27N5O

473.57

BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhi

C(NC1=CC(CNC)=CC=C1C)(=O)C1=CC=C(NC2=NC(C3=CC=CC=C3)=C3C(=N2)C=CC=C3)C=C1

12352200