Bio-Connect

BMS-986260

HY-W107024
MedChem Express
Estimated Purity98.03
Product group Chemicals
Molecular Weight382.78
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    MedChem Express
  • Product Name
    BMS-986260
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    98.03
  • Molecular Formula
    C18H12ClFN6O
  • Molecular Weight
    382.78
  • Scientific Description
    BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFbetaR1 inhibitor ( IC 50 =1.6 nM). BMS-986260 displays exquisite selectivity for TGFbetaR1 over its isozyme TGFbetaR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFbeta mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC 50 of 350 nM and 190 nM, respectively [1] .
  • SMILES
    N#CC1=CN=C2C=CC(C3=C(C4=CC=C(F)C(Cl)=C4)N=CN3CCO)=NN21
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200