BMS-986260

MedChem Express

BMS-986260

10

Research Use Only

98.03

C18H12ClFN6O

382.78

BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFbetaR1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGFbetaR1 over its isozyme TGFbetaR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFbeta mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively[1].

N#CC1=CN=C2C=CC(C3=C(C4=CC=C(F)C(Cl)=C4)N=CN3CCO)=NN21

-20°C,2°C to 8°C

12352200