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BOB.1 (B-Cell Marker) (BOB1/2423), CF405S conjugate, 0.1mg/mL [26628-22-8]

BOB.1 (B-Cell Marker) (BOB1/2423), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042423
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetPOU2AF1
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Overview

  • Supplier
    Biotium
  • Product Name
    BOB.1 (B-Cell Marker) (BOB1/2423), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    BOB1/2423
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID5450
  • Target name
    POU2AF1
  • Target description
    POU class 2 homeobox associating factor 1
  • Target synonyms
    B-cell-specific coactivator OBF-1; BOB1; BOB-1; OBF1; OBF-1; OCAB; OCA-B; OCT-binding factor 1; POU class 2 associating factor 1; POU domain class 2-associating factor 1
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ16633
  • Protein Name
    POU domain class 2-associating factor 1
  • Scientific Description
    BOB-1 is a transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2, boosting the promoter activity of those complexes. It is essential for the response of B-cells to antigens, required for the formation of germinal centers, and regilates IL-6 expression. BOB-1 expression in a variety of established B-cell lines, representing different stages of B-cell development, has suggested a constitutive, B-cell-specific expression pattern. LP cells in nodular lymphocyte predominant Hodgkin lymphoma, because they are germinal center-derived, are consistently immuno-positive for BOB-1. Conversely, only some cases of classical Hodgkin lymphoma show BOB-1 immuno-reactivity within the Hodgkin and Reed-Sternberg cells. Expression of BOB-1 has been reported in follicular center cell lymphoma, diffuse large B-cell lymphoma and some cases of acute myeloid leukemia. B-CLL, marginal zone lymphoma, and mantle cell lymphoma may show weak to moderate immunoreactivity. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203