Boc-L-Phe(4-NH-Poc)-OH [2576508-03-5]

TargetMol Chemicals

Boc-L-Phe(4-NH-Poc)-OH [2576508-03-5]

9

Research Use Only

C18H22N2O6

362.38

Boc-L-Phe(4-NH-Poc)-OH is a chemical reagent with an azido group used in peptide synthesis as a protected orthogonal building block. The propargyl group, commonly abbreviated as Poc or Pryoc, serves as a standard alkyne component for click conjugation and can be combined with tetrazine connectors in copper-free Diels-Alder type click reactions. It also acts as a special protective group for amines, hydroxyls, and esters, stable under neat TFA but can undergo TFA:DCM cleavage with Co2(CO)8 at room temperature. Deprotection reports with other transition metals such as palladium exist. Additionally, Boc-L-Phe(4-NH-Poc)-OH contains an Alkyne group that reacts with azide-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).

C([C@H](NC(OC(C)(C)C)=O)C(O)=O)C1=CC=C(NC(OCC#C)=O)C=C1

-20°C

12352200