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ProductsBack/BOK Antibody, FITC conjugated

BOK Antibody, FITC conjugated

Research Use Only
CSB-PA892353LC01HU
Cusabio
ReactivityHuman
Product group Antibodies
TargetBOK
Price on request
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ISO certified
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Overview

  • Supplier
    Cusabio
  • Product Name
    BOK Antibody, FITC conjugated
  • Delivery Days Customer
    20
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    FITC
  • Gene ID666
  • Target name
    BOK
  • Target description
    BCL2 family apoptosis regulator BOK
  • Target synonyms
    BCL2 related ovarian killer; BCL2L9; bcl2-L-9; bcl-2-like protein 9; bcl-2-related ovarian killer protein; BOK, BCL2 family apoptosis regulator; BOKL; hBOK
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9UMX3
  • Protein Name
    Bcl-2-related ovarian killer protein
  • Scientific Description
    Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apototic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203