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ProductsBack/Bostrycin [21879-81-2]
Chemical Structure
Chemical Structure
Chemical Structure

Bostrycin [21879-81-2]

Research Use Only
AG-CN2-0175
AdipoGen Life Sciences
CAS Number21879-81-2
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight336.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Bostrycin [21879-81-2]
  • Delivery Days Customer
    10
  • CAS Number
    21879-81-2
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C16H16O8
  • Molecular Weight
    336.3
  • Scientific Description
    Anthraquinone antibiotic. Red antibacterial agent against Gram positive bacteria. Anticancer agent. Inhibits cell proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway. Also shown to block cell cycle at G1 phase leading to cell death. Induced mitochondria-mediated apoptosis in the yeast Saccharomyces cerevisiae. Weak in vitro inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase (MptpB). Potential red-colored agent for food processing. - Chemical. CAS: 21879-81-2. Formula: C16H16O8. MW: 336.3. Isolated from fungus Arthrinium sp. Anthraquinone antibiotic. Red antibacterial agent against Gram positive bacteria. Anticancer agent. Inhibits cell proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway. Also shown to block cell cycle at G1 phase leading to cell death. Induced mitochondria-mediated apoptosis in the yeast Saccharomyces cerevisiae. Weak in vitro inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase (MptpB). Potential red-colored agent for food processing.
  • SMILES
    O=C(C(OC)=C1)C2=C(C(O)=C([C@H](O)[C@@H](O)[C@](O)(C)C3)C3=C2O)C1=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Structure of bostrycin: T. Noda, et al.; Tetrahed. Lett. 9, 6087 (1968)
  • The structure of bostrycin: T. Noda, et al.; Tetrahedron 26, 1339 (1970)
  • The antibiotic bostrycin from Alternaria Eichhorniae: K.L. Stevens, et al.; Phytochem. 18, 1579 (1979)
  • Bostrycin: S.Y. Chen, et al.; Acta Crystallogr. Sect. E Struct. Rep. Online 64, o2226 (2008)
  • The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeast Saccharomyces cerevisiae: C. Xu, et al.; FEMS Yeast Res. 10, 297 (2010)
  • Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway: W.S. Chen, et al.; J. Exp. Clin. Cancer Res. 30, 17 (2011)
  • Bostrycin, a novel coupling agent for protein immobilization and prevention of biomaterial-centered infection produced by Nigrospora sp. No. 407: W.J. Yang, et al.; Enzyme Microb. Technol. 50, 287 (2012)
  • Studies on the synthesis of derivatives of marine-derived bostrycin and their structure-activity relationship against tumor cells: H. Chen, et al.; Mar. Drugs 10, 932 (2012)
  • Identification of Bostrycin Derivatives as Potential Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase (MptpB): D.N. Chen, et al.; Med. Chem. 12, 296 (2016)
  • Bostrycin production by agro-industrial residues and its potential for food processing: Y.-H. Huang, et al.; Food Sci. Biotech. 26, 715 (2017)