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ProductsBack/BQ-123 . sodium salt [136553-81-6]
Chemical Structure
Chemical Structure
Chemical Structure

BQ-123 . sodium salt [136553-81-6]

Research Use Only
AG-CP3-0001
AdipoGen Life Sciences
CAS Number136553-81-6
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight609.7 . 23.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    BQ-123 . sodium salt [136655-57-7]
  • Delivery Days Customer
    10
  • CAS Number
    136553-81-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C31H42N6O7 . Na
  • Molecular Weight
    609.7 . 23.0
  • Scientific Description
    Chemical. CAS: 136655-57-7. Formula: C31H42N6O7 . Na. MW: 609.7 . 23.0. Synthetic. Potent and selective endothelin receptor A (ETA) antagonist. Suppresses the ET-1-induced decrease of LPL activity. Shows protective effects in ischemic acute renal failure. Neuroprotective. Anti-hypertensive. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation. Cardiovascular agent. Reduces myocardial infarct size and oxidant injury. Selected Reviews. - Potent and selective endothelin receptor A (ETA) antagonist [1-3]. Suppresses the ET-1-induced decrease of LPL activity [4]. Shows protective effects in ischemic acute renal failure [5]. Neuroprotective [6, 10]. Anti-hypertensive [7]. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation [8]. Cardiovascular agent [9]. Reduces myocardial infarct size and oxidant injury [11]. Selected Reviews [12, 13].
  • SMILES
    [Na+].CC(C)CC1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC([O-])=O)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC1=O)C(C)C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor: M. Ihara, et al.; J. Cardiovasc. Pharmacol. 20, S11 (1992)
  • BQ-123, cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu), is a non-competitive antagonist of the actions of endothelin-1 in SK-N-MC human neuroblastoma cells: C.R. Hiley, et al.; BBRC 184, 504 (1992)
  • Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor: M. Ihara, et al.; Life Sci. 50, 247 (1992)
  • Suppressive effects of the endothelin receptor (ETA) antagonist BQ-123 on ET-1-induced reduction of lipoprotein lipase activity in 3T3-L1 adipocytes: F. Ishida, et al.; Biochem. Pharmacol. 44, 1431 (1992)
  • Protective effect of a selective endothelin receptor antagonist, BQ-123, in ischemic acute renal failure in rats: N. Mino, et al.; Eur. J. Pharmacol. 221, 77 (1992)
  • Peptidic endothelin-1 receptor antagonist, BQ-123, and neuroprotection: G. Feuerstein, et al.; Peptides 15, 467 (1994)
  • BQ-123, a selective endothelin subtype A-receptor antagonist, lowers blood pressure in different rat models of hypertension: S.A. Douglas, et al.; J. Hypertens. 12, 561 (1994)
  • Inhibitory effect of BQ-123 on endothelin-1-stimulated mitogen-activated protein kinase and cell growth of rat vascular smooth muscle cells: X. Guo, et al.; Hypertens. Res. 19, 23 (1996)
  • Inhibition of myocardial endothelin pathway improves longterm survival in heart failure: S. Sakai, et al.; Nature 384, 353 (1996)
  • Similar protective effects of BQ-123 and erythropoietin on survival of neural cells and generation of neurons upon hypoxic injury: L. Danielyan, et al.; Eur. J. Cell Biol. 84, 907 (2005)