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ProductsBack/Bractoppin [2290527-07-8]
Bractoppin [2290527-07-8]

Bractoppin [2290527-07-8]

T8873
TargetMol Chemicals
CAS Number2290527-07-8
DownloadMSDS
Product group Chemicals
Estimated Purity99.65%
Molecular Weight414.47
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Bractoppin [2290527-07-8]
  • Delivery Days Customer
    10
  • CAS Number
    2290527-07-8
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Bractoppin
  • Estimated Purity
    99.65%
  • Molecular Formula
    C25H23FN4O
  • Molecular Weight
    414.47
  • Scientific Description
    Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 microM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
  • Shelf life instruction
    3 years
  • SMILES
    Fc1ccccc1CN1CCN(CC1)C(=O)c1ccc2[nH]c(nc2c1)-c1ccccc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. Periasamy J et al., 2018 Jun 21, Cell Chem Biol
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