Braftide

MedChem Express

Braftide

5

Research Use Only

99.68

Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF G469A with IC 50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells ( EC 50 is 7.1 and 6.6 microM, for HCT116 and HCT-15), in combination of TAT sequence [1] .

-20°C,-80°C

12352202