BRD9876

MedChem Express

BRD9876 [32703-82-5]

10

32703-82-5

Research Use Only

98.82

C16H14N2

234.30

BRD9876 is the rigor inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the alpha4-alpha6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research [1] [2] [3] [4] .

CC(C)(C1=CC2=CC(C#N)=C(C#N)C=C2C=C1)C

2°C to 8°C

12352200