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ProductsBack/(+)-Brefeldin A [20350-15-6]
Chemical Structure
Chemical Structure
Chemical Structure

(+)-Brefeldin A [20350-15-6]

Research Use Only
AG-CN2-0018
AdipoGen Life Sciences
CAS Number20350-15-6
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight280.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    (+)-Brefeldin A [20350-15-6]
  • Delivery Days Customer
    10
  • CAS Number
    20350-15-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C16H24O4
  • Molecular Weight
    280.4
  • Scientific Description
    Chemical. CAS: 20350-15-6. Formula: C16H24O4. MW: 280.4. Isolated from Penicillium janthinellum. Protein transport from ER to Golgi inhibitor. ADP-ribosylation factor (Arf) inhibitor. Cytotoxic. Antibiotic. Antiviral. Apoptosis inducer. Antitumor compound. Intracellular collagen degradation inhibitor. Reviews. - Protein transport from ER to Golgi inhibitor [2, 3]. ADP-ribosylation factor (Arf) inhibitor [6]. Cytotoxic [1]. Antibiotic [8]. Antiviral [8]. Apoptosis inducer [5]. Antitumor compound [9]. Intracellular collagen degradation inhibitor [7]. Reviews [4, 7, 8].
  • SMILES
    C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2C(O)\C=C\C(=O)O1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
  • Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986)
  • Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988)
  • Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992) (Review)
  • Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996)
  • Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF: J.B. Helms & J.E. Rothman; Nature 360, 352 (1992)
  • Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002) (Review)
  • Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective: V. Betina; Folia Microbiol. (Praha) 37, 3 (1992) (Review)
  • The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro: D.E. Larsson, et al.; Anticancer Res. 30, 149 (2010)