Bretazenil

MedChem Express

Bretazenil

9

84379-13-5

Research Use Only

99.13

C19H20BrN3O3

418.28

Bretazenil (Ro 16-6028) is a partial agonist at the gamma-aminobutyric acid A (GABAA) receptor-linked benzodiazepine site. Bretazenil is potent benzodiazepine examined, exhibiting an IC50 (concentration at which half-maximal inhibition of specific [35S]TBPS binding occurs) of 6.1 nM. Bretazenil shows an EC50 of 10 nM for recombinant alpha1beta1gamma2. Anticonvulsant effects[1][2][3].

CC(C)(C)OC(C1=C2N(C=N1)C3=CC=CC(Br)=C3C(N4[C@@]2([H])CCC4)=O)=O

-20°C,2°C to 8°C

12352200