Brexpiprazole-d8

MedChem Express

Brexpiprazole-d8 [1427049-21-5]

5

1427049-21-5

Research Use Only

99.90

C25H19D8N3O2S

441.62

Brexpiprazole-d8 (OPC-34712-d8) is the deuterium labeled Brexpiprazole (HY-15780). Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic alpha1B (Ki=0.17 nM) and alpha2C receptors (Ki=0.59 nM)[2][3].

O=C1NC2=C(C=CC(OCCCCN3C([2H])([2H])C([2H])([2H])N(C4=C(C=CS5)C5=CC=C4)C([2H])([2H])C3([2H])[2H])=C2)C=C1

-20°C

12352200