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Chemical Structure
Chemical Structure
Chemical Structure

Brigatinib

CDX-B0374
Chemodex
CAS Number1197953-54-0
Product group Chemicals
Estimated Purity>98%
Molecular Weight584.09
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Overview

  • Supplier
    Chemodex
  • Product Name
    Brigatinib [1197953-54-0]
  • Delivery Days Customer
    10
  • CAS Number
    1197953-54-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C29H39ClN7O2P
  • Molecular Weight
    584.09
  • Scientific Description
    Brigitanib acts as a tyrosine kinase inhibitor with activity against multiple kinases including ALK, ROS1, insulin-like growth factor 1 receptor and against EGFR deletions and point mutations. It acts by inhibiting ALK phosphorylation and the activation of downstream signaling proteins. It is a highly potent and selective inhibitor of anaplastic lymphoma kinase (ALK). Blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants. It is potentially useful for the treatment of non-small cell lung cancer (NSCLC). Can be used in combination with anti-EGFR drugs to overcome EGFR mutation resistance. - Chemical. CAS: 1197953-54-0. Formula: C29H39ClN7O2P. MW: 584.09. Synthetic. Brigitanib acts as a tyrosine kinase inhibitor with activity against multiple kinases including ALK, ROS1, insulin-like growth factor 1 receptor and against EGFR deletions and point mutations. It acts by inhibiting ALK phosphorylation and the activation of downstream signaling proteins. It is a highly potent and selective inhibitor of anaplastic lymphoma kinase (ALK). Blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants. It is potentially useful for the treatment of non-small cell lung cancer (NSCLC). Can be used in combination with anti-EGFR drugs to overcome EGFR mutation resistance.
  • SMILES
    CN1CCN(C2CCN(C3=CC=C(NC4=NC(NC5=CC=CC=C5P(C)(C)=O)=C(Cl)C=N4)C(OC)=C3)CC2)CC1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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