Brilanestrant (GDC-0810)

Selleck Chemicals

Brilanestrant (GDC-0810) [1365888-06-7]

9

Research Use Only

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Brilanestrant (GDC-0810, ARN-810) is a potent ER-alpha binder (ER-alpha, IC50 = 6.1 nM; ER-beta, IC50 = 8.8 nM), a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER-alpha degradation (EC50 = 0.7 nM) and MCF-7 breast cancer cell viability (IC50 = 2.5 nM) assays with good selectivity over other nuclear hormone receptors.

-80°C

51202000