BRK1 Polyclonal Antibody

Reddot Biotech

BRK1 Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.6 mg/ml

Unconjugated

BRK1

BRICK1 subunit of SCAR/WAVE actin nucleating complex

BRICK1, SCAR/WAVE actin nucleating complex subunit; C3orf10; haematopoietic stem/progenitor cell protein 300; hHBrk1; HSPC300; MDS027; protein BRICK1

Rabbit

IgG

HSPC300 (hematopoietic stem cell protein 300) is also known as probable protein BRICK1 or C3orf10 (chromosome 3 open reading frame 10) and is a 75 amino acid protein that is expressed as two isoforms and localizes to both the cytoplasm and the cytoskeleton. HSPC300 is thought to regulate cytoskeletal organization and Actin polymerization. Free HSPC300 exists as homotrimers prior to its incorporation into the WAVE complex. The WAVE complex includes five proteins, one of which is HSPC300, that regulate the ARC (Arp2/3 complex) which is responsible for Actin nucleation and is Rac 1-dependent. Because HSPC300 is a highly conserved subunit of the WAVE complex across many species, it is thought to have the same or similar functions in many different organisms.

Human, Mouse

-20°C

12352203