BS-181 [1092443-52-1]

MedChem Express

BS-181 [1092443-52-1]

9

1092443-52-1

Research Use Only

98.10

C22H32N6

380.53

BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 microM-37.3 microM) and induces cell apoptosis. BS-181 has the potential for the research of cancer therapy[1][2].

CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C

-20°C,2°C to 8°C

12352200