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BS-181 (dihydrochloride)

HY-110368
MedChem Express
CAS Number1883548-83-1
Product group Chemicals
Molecular Weight453.45
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Overview

  • Supplier
    MedChem Express
  • Product Name
    BS-181 (dihydrochloride) [1883548-83-1]
  • Delivery Days Customer
    10
  • CAS Number
    1883548-83-1
  • Certification
    Research Use Only
  • Molecular Formula
    C22H34Cl2N6
  • Molecular Weight
    453.45
  • Scientific Description
    BS-181 dihydrochloride is a potent and selective CDK7 inhibitor ( IC 50 =21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC 50 values of 880 nM, 3000 nM and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 dihydrochloride inhibits a panel of cancer cells growth (IC 50 =11.5 microM-37.3 microM) and induces cell apoptosis . BS-181 dihydrochloride has the potential for the research of cancer therapy [1] [2] .
  • SMILES
    CC(C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCCCCCCN)C.Cl.Cl
  • UNSPSC
    12352200