BSO (L-Buthionine-(S,R)-sulfoximine) [83730-53-4]

Selleck Chemicals

BSO (L-Buthionine-(S,R)-sulfoximine) [83730-53-4]

9

Research Use Only

BSO (L-Buthionine-(S,R)-sulfoximine, L-Buthionine sulfoximine) is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase (γ-glutamylcysteine synthetase, γ-GCS) and depletes cellular glutathione levels. The IC50 of BSO on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.

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