BUB1B Antibody
![Research Use Only](static/images/certificates/ruo.jpg)
CSB-RA263021A0HU
ApplicationsFlow Cytometry, Western Blot, ELISA
Product group Antibodies
ReactivityHuman
Overview
- SupplierCusabio
- Product NameBUB1B Antibody
- Delivery Days Customer20
- ApplicationsFlow Cytometry, Western Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID7H4
- ConjugateUnconjugated
- IsotypeIgG
- Scientific DescriptionEssential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203