C5 / C5a antibody [561]

GeneTex

C5 / C5a antibody [561]

9

Monoclonal antibody 561 recognizes the N-terminus of C5. The antibody reacts both with intact C5 (190 kDa) as with C5a (115 kDa).

*Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Functional Assay, ELISA

Research Use Only

Monoclonal

561

100 ug/ml

Unconjugated

C5

complement C5

anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a; C5a anaphylatoxin; C5b; C5D; complement C5; complement component 5; CPAMD4; ECLZB; prepro-C5

Mouse

IgG2a

Complement C5

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Human

2°C to 8°C

12352203