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ProductsBack/(+/-)-C75 [191282-48-1]
Chemical Structure
Chemical Structure
Chemical Structure

(+/-)-C75 [191282-48-1]

Research Use Only
AG-CR1-2904
AdipoGen Life Sciences
CAS Number191282-48-1
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight254.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    C75 (FASN Inhibitor) [191282-48-1]
  • Delivery Days Customer
    10
  • CAS Number
    191282-48-1
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C14H22O4
  • Molecular Weight
    254.3
  • Scientific Description
    Chemical. CAS: 191282-48-1. Formula: C14H22O4. MW: 254.3. . Stable synthetic cerulenin derivative. Competitive irreversible fatty acid synthase (FASN) inhibitor that acts on KR, ACP and TE domains. Used to study fatty acid synthesis in metabolic disorders and cancer. Useful agent for immunometabolism research. Anorexigenic agent, activating CPT1 to accelerate fatty acid beta-oxidation. Shown to inhibit food intake through AMPK-related pathways. Cytotoxic to many cancer cell lines. Antitumor agent shown to suppress DNA replication and induce apoptosis. - Stable synthetic cerulenin derivative. Competitive irreversible fatty acid synthase (FASN) inhibitor that acts on ketoreductase (KR), acyl carrier protein (ACP) and thioesterase (TE) domains. Used to study fatty acid synthesis in metabolic disorders and cancer. Useful agent for immunometabolism research. Anorexigenic agent, activating CPT1 to accelerate fatty acid beta-oxidation. Shown to inhibit food intake through AMPK-related pathways. Cytotoxic to many cancer cell lines. Antitumor agent shown to suppress DNA replication and induce apoptosis. Specifically blocks TLR/MYD88 signaling in neutrophils.
  • SMILES
    O=C(OC(CCCCCCCC)C1C(O)=O)C1=C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines: E.S. Pizer, et al.; Cancer Res. 58, 4611 (1998)
  • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors: T.M. Loftus, et al.; Science 288, 2379 (2000)
  • Synthesis and antitumor activity of an inhibitor of fatty acid synthase: F.P. Kuhajda, et al.; PNAS 97, 3450 (2000)
  • Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides: T. Shimokawa, et al.; PNAS 99, 66 (2002)
  • C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity: J.N. Thupari, et al.; PNAS 99, 9498 (2002)
  • The anorexigenic fatty acid synthase inhibitor, C75, is a nonspecific neuronal activator: K.A. Takahashi, et al.; Endocrinol. 145, 184 (2004)
  • Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3: S.H. Cha, et al.; BBRC 317, 301 (2004)
  • C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism: L.E. Landree, et al.; J. Biol. Chem. 279, 3817 (2004)
  • A guide to immunometabolism for immunologists: L.A. O'Neill, et al.; Nat. Rev. Immunol. 16, 553 (2016)
  • Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors: G. Andrejeva & J.C. Rathmell; Cell Metab. 26, 49 (2017)