CA8 Polyclonal Antibody

Reddot Biotech

CA8 Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

CA8

carbonic anhydrase 8

CALS; CAMRQ3; carbonate dehydratase; carbonic anhydrase VIII; carbonic anhydrase-like sequence; carbonic anhydrase-related protein; CA-related protein; CARP; CA-RP; CA-VIII

Rabbit

IgG

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.

Human, Mouse

-20°C

12352203