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Calcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF405S conjugate, 0.1mg/mL [26628-22-8]

Calcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC042266
Biotium
ApplicationsImmunoFluorescence, Western Blot
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetCHP2
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Overview

  • Supplier
    Biotium
  • Product Name
    Calcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    CPTC-CHP2-1
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID63928
  • Target name
    CHP2
  • Target description
    calcineurin like EF-hand protein 2
  • Target synonyms
    calcineurin B homologous protein 2; hepatocellular carcinoma antigen gene 520; hepatocellular carcinoma-associated antigen 520
  • Host
    Mouse
  • Isotype
    IgG2c
  • Protein IDO43745
  • Protein Name
    Calcineurin B homologous protein 2
  • Scientific Description
    Calcineurin B homologous protein 2, also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na/H exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203