![Calcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF405S conjugate, 0.1mg/mL [26628-22-8] Calcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF405S conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2021/02/view_image-48.jpeg)
Calcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF405S conjugate, 0.1mg/mL [26628-22-8]
BNC042266
ApplicationsImmunoFluorescence, Western Blot
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetCHP2
Overview
- SupplierBiotium
- Product NameCalcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF405S conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsImmunoFluorescence, Western Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCPTC-CHP2-1
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID63928
- Target nameCHP2
- Target descriptioncalcineurin like EF-hand protein 2
- Target synonymscalcineurin B homologous protein 2; hepatocellular carcinoma antigen gene 520; hepatocellular carcinoma-associated antigen 520
- HostMouse
- IsotypeIgG2c
- Protein IDO43745
- Protein NameCalcineurin B homologous protein 2
- Scientific DescriptionCalcineurin B homologous protein 2, also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na/H exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203