Calpain 1 Antibody / CAPN1

Biorbyt

Calpain 1 Antibody / CAPN1

16

Optimal dilution of the antibody should be determined by the researcher.

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Immunohistochemistry (FFPE): 1-2ug/ml IHC-P

Research Use Only

Monoclonal

CAPN1/1530

Unconjugated

CAPN1

calpain 1

calcium-activated neutral proteinase 1; calpain 1, (mu/I) large subunit; calpain mu-type; calpain, large polypeptide L1; calpain-1 catalytic subunit; calpain-1 large subunit; CANP; CANP 1; CANP1; CANPL1; cell proliferation-inducing gene 30 protein; cell proliferation-inducing protein 30; micromolar-calpain; muCANP; muCL; SPG76

Mouse

IgG1

Calpain-1 catalytic subunit

Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

Human

-20°C,2°C to 8°C

12352203