Bio-Connect

CAMLG Polyclonal Antibody

RD81583A
Reddot Biotech
ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetCAMLG
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    CAMLG Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID819
  • Target name
    CAMLG
  • Target description
    calcium modulating ligand
  • Target synonyms
    calcium signal-modulating cyclophilin ligand; calcium-modulating cyclophilin ligand; CAML; cyclophilin B-binding protein; GET2; guided entry of tail-anchored proteins factor CAMLG
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203