Caspase-3 Antibody, Pro and Active

Biorbyt

Caspase-3 Antibody, Pro and Active

16

This antibody will detect the pro form and p17 and p12 active forms of Caspase-3.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Western blot: 2-4ug/ml,IHC (FFPE): 5ug/ml IHC-P, WB

Research Use Only

Monoclonal

CAS3836

Unconjugated

CASP3

caspase 3

apopain; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP32; CPP-32; CPP32B; cysteine protease CPP32; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1

Mouse

IgG1

Caspases, or cysteine-aspartic proteases, are a family of cysteine proteases that play essential roles in inflammation, apoptosis and necrosis. They are often referred to as the executioners of apoptosis. Caspases are synthesized as inactive proenzymes comprising an N-terminal peptide (prodomain) together with one large and one small subunit. Active caspase-1 and -3 are heterodimers, containing two small and two large subunits. Active Caspase-3 subunits are 17kD (p17) and 12kD (p12). Pro Caspase-3 is inactive and has virtually no activity until it is cleaved by an initiator caspase. It is activated by Caspases -8, -9 and -10 (initiator caspases) and then effects apoptosis by cleaving targeted cellular proteins.

Human, Mouse, Rat

-20°C

12352203