Caspase-5 Polyclonal Antibody
RD266918A
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetCASP5
Overview
- SupplierReddot Biotech
- Product NameCaspase-5 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID838
- Target nameCASP5
- Target descriptioncaspase 5
- Target synonymscaspase 5 variant X1; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; caspase-5; ICE(rel)III; ICEREL-III; ICH-3; protease ICH-3; protease TY; TY protease
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203