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ProductsBack/(+)-Catechin . hydrate [225937-10-0]
Chemical Structure
Chemical Structure
Chemical Structure

(+)-Catechin . hydrate [225937-10-0]

Research Use Only
AG-CN2-0407
AdipoGen Life Sciences
CAS Number225937-10-0
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight290.3 . 18.0
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    (+)-Catechin . hydrate [225937-10-0, 88191-48-4]
  • Delivery Days Customer
    10
  • CAS Number
    225937-10-0
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C15H14O6 . H2O
  • Molecular Weight
    290.3 . 18.0
  • Scientific Description
    Chemical. CAS: 225937-10-0 or 88191-48-4. Formula: C15H14O6 . H2O. MW: 290.3 . 18.0. Isolated from Uncaria rhynchophylla. Specific histidine decarboxylase inhibitor. Anti-inflammatory. COX-1 inhibitor. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation. Antimetastatic and anticancer compound. Antiangiogenic. Anti-osteoporotic. Antibacterial and antifungal. Neuroprotective. Mono oxidase B inhibitor. Apoptosis and cell cycle arrest inducer. JNK phosphorylation inhibitor. Antispasmodic. Insulin-mimetic. - Specific histidine decarboxylase inhibitor [1]. Anti-inflammatory. COX-1 inhibitor [2]. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation [3, 6, 9]. Antimetastatic and anticancer compound [4, 9, 10, 14, 16, 17]. Antiangiogenic [14]. Anti-osteoporotic [5]. Antibacterial and antifungal [7]. Neuroprotective [8]. Mono oxidase B inhibitor [11]. Apoptosis and cell cycle arrest inducer [9, 10, 16, 17]. JNK phosphorylation inhibitor [12]. Antispasmodic [13]. Insulin-mimetic [15].
  • SMILES
    O.O[C@H]1CC2=C(O)C=C(O)C=C2O[C@@H]1C1=CC=C(O)C(O)=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro: H.J. Reimann, et al.; Agents Actions 7, 69 (1977)
  • Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis: Y. Noreen, et al.; Planta Med. 64, 520 (1998)
  • (+)-Catechin as antioxidant: mechanisms preventing human plasma oxidation and activity in red wines: S.B. Lotito & C.G. Fraga; Biofactors 10, 125 (1999)
  • Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002) (Review)
  • Effects of (+)-catechin on the function of osteoblastic cells: E.M. Choi & J.K. Hwang; Biol. Pharm. Bull. 26, 523 (2003)
  • Dietary supplementation of (+)-catechin protects against UVB-induced skin damage by modulating antioxidant enzyme activities: S.E. Jeon, et al.; Photodermatol. Photoimmunol. Photomed. 19, 235 (2003)
  • Phytotoxic and antimicrobial activities of catechin derivatives: R. Veluri, et al.; J. Agric. Food Chem. 52, 1077 (2004)
  • Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases: S. Mandel & M.B. Youdim; Free Radic. Biol. Med. 37, 304 (2004) (Review)
  • A green tea component, catechin, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo: L. Gordon; Haematologica 90, 290 (2005)
  • (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest: Q. Huang, et al.; J. Pharmacol. Sci. 98, 16 (2005)