WB analysis of HeLa cells treated with etoposide 25uM (1h) lysate using GTX86946 Cathepsin L (cleaved Thr288) antibody. The lane on the right is blocked with the synthesized peptide.
WB analysis of HeLa cells treated with etoposide 25uM (1h) lysate using GTX86946 Cathepsin L (cleaved Thr288) antibody. The lane on the right is blocked with the synthesized peptide.
Cathepsin L (cleaved Thr288) antibody
GTX86946
Overview
- SupplierGeneTex
- Product NameCathepsin L (cleaved Thr288) antibody
- Delivery Days Customer9
- Antibody SpecificityCathepsin L (cleaved Thr288) antibody detects endogenous levels of fragment of activated CATL1 resulting from cleavage adjacent to Thr288.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1514
- Target nameCTSL
- Target descriptioncathepsin L
- Target synonymscathepsin L1; CATL; CTSL1; major excreted protein; MEP; procathepsin L
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203