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Caveolin 3 antibody [N1N2], N-term

Name: Caveolin 3 antibody [N1N2], N-term
SKU: GTX109650_G10
Availability: BackOrder

GTX109650

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetCAV3

Overview

Supplier
GeneTex
Product Name
Caveolin 3 antibody [N1N2], N-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:20000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID859
Target name
CAV3
Target description
caveolin 3
Target synonyms
LGMD1C, LQT9, MPDT, RMD2, VIP-21, VIP21, caveolin-3, M-caveolin, cavolin 3
Host
Rabbit
Isotype
IgG
Protein IDP56539
Protein Name
Caveolin-3
Scientific Description
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Böhm J, Biancalana V, Malfatti E, et al. Adult-onset autosomal dominant centronuclear myopathy due to BIN1 mutations. Brain. 2014,137(Pt 12):3160-70. doi: 10.1093/brain/awu272
Read this paper
Ullrich ND, Fischer D, Kornblum C, et al. Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle. Hum Mutat. 2011,32(3):309-17. doi: 10.1002/humu.21431
Read this paper