CBFA2T2 Polyclonal Antibody

Reddot Biotech

CBFA2T2 Polyclonal Antibody

5

ImmunoFluorescence, Western Blot

Research Use Only

1 mg/ml

Unconjugated

CBFA2T2

CBFA2/RUNX1 partner transcriptional co-repressor 2

CBFA2/RUNX1 translocation partner 2; core-binding factor, runt domain, alpha subunit 2; translocated to, 2; EHT; ETO homolog on chromosome 20; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; MTGR1; myeloid translocation gene-related protein 1; myeloid translocation-related protein 1; p85; protein CBFA2T2; ZMYND3

Rabbit

IgG

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5-region of the RUNX1 (AML1) gene fused to the 3-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Human, Mouse, Rat

-20°C

12352203