Cbl-b-IN-15

MedChem Express

Cbl-b-IN-15

14

Research Use Only

C27H27N5O3

469.53

Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM). Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 microM[1].

O=C1[C@@H](NC(C2=CC=CC=C2CN3CCO[C@@H](C)C3)=O)N=C(C4=CC=CC=C4)C5=CC=NC=C5N1

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