cBu-Cit-PROTAC BRD4 Degrader-5

MedChem Express

cBu-Cit-PROTAC BRD4 Degrader-5

5

Research Use Only

C79H99ClN16O16S2

1628.31

cBu-Cit-PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 by association with cBu-Cit. cBu-Cit-PROTAC BRD4 Degrader-5 can effectively inhibit BRD4 in HER2 positive and negative breast cancer cell lines. cBu-Cit-PROTAC BRD4 Degrader-5 has a single bond and can be conjugated to an ADC antibody to form a PAC[1].

CC1=C(C)SC(N2C3=NN=C2C)=C1C(C4=CC=C(C=C4)Cl)=N[C@H]3CC(NCCOCCOCCOCC(N[C@H](C(N5C[C@@H](C[C@H]5C(NCC(C=C6)=CC=C6C7=C(C)N=CS7)=O)OCNC(OCC8=CC=C(NC([C@@H](NC(C9(C(NCCCCCN%10C(C=CC%10=O)=O)=O)CCC9)=O)CCCNC(N)=O)=O)C=C8)=O)=O)C(C)(C)C)=O)=O

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